Drug interactions
Amobarbital + Lofexidine
Severity: Moderate
Amobarbital and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine causes sedation and hypotension, and amobarbital adds to CNS depression. Together they may cause excessive drowsiness, bradycardia and low blood pressure.
What this interaction means in plain words
Amobarbital and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Lofexidine belongs to Central Nervous System.
Why it happens
Additive CNS depression from alpha-2 agonism and barbiturate GABA-A potentiation.
What to do
Monitor sedation, blood pressure and heart rate, and reduce doses if excessive drowsiness or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Amobarbital with Lofexidine?
MediHelp rates the interaction as moderate. Amobarbital and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine causes sedation and hypotension, and amobarbital adds to CNS depression. Together they may cause excessive drowsiness, bradycardia and low blood pressure.
How serious is the interaction between Amobarbital and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and heart rate, and reduce doses if excessive drowsiness or hypotension occurs.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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