Drug interactions
Amobarbital + Mavacamten
Severity: Major
Amobarbital and Mavacamten: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten is cleared mainly by CYP2C19 and CYP3A4, and barbiturate induction lowers its concentrations. Reduced exposure may blunt the therapeutic effect on outflow obstruction. Labeling advises against use with strong inducers of these enzymes.
What this interaction means in plain words
Amobarbital and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Mavacamten belongs to Cardiovascular.
Why it happens
Barbiturate induction of CYP2C19 and CYP3A4 accelerates mavacamten clearance.
What to do
Avoid the combination where possible. If used, monitor echocardiographic response (LVOT gradient, LVEF) and adjust mavacamten dosing accordingly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Amobarbital with Mavacamten?
MediHelp rates the interaction as major. Amobarbital and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mavacamten is cleared mainly by CYP2C19 and CYP3A4, and barbiturate induction lowers its concentrations. Reduced exposure may blunt the therapeutic effect on outflow obstruction. Labeling advises against use with strong inducers of these enzymes.
How serious is the interaction between Amobarbital and Mavacamten?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, monitor echocardiographic response (LVOT gradient, LVEF) and adjust mavacamten dosing accordingly.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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