Drug interactions
Amobarbital + Metformin-pioglitazone
Severity: Minor
Amobarbital and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital is an enzyme inducer and may lower pioglitazone concentrations, which are partly cleared by CYP2C8 and CYP3A4. Reduced glucose-lowering effect is possible but typically modest.
What this interaction means in plain words
Amobarbital and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amobarbital belongs to Central Nervous System; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Induction of hepatic CYP enzymes increases pioglitazone metabolism.
What to do
Monitor glycemic control when starting or stopping amobarbital and adjust the pioglitazone dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Amobarbital and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amobarbital is an enzyme inducer and may lower pioglitazone concentrations, which are partly cleared by CYP2C8 and CYP3A4. Reduced glucose-lowering effect is possible but typically modest.
How serious is the interaction between Amobarbital and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control when starting or stopping amobarbital and adjust the pioglitazone dose if needed.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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