Drug interactions
Amobarbital + Metformin-repaglinide
Severity: Moderate
Amobarbital and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital can induce hepatic enzymes and lower repaglinide concentrations, reducing glycemic control. Loss of effect may occur during chronic barbiturate use.
What this interaction means in plain words
Amobarbital and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Metformin-repaglinide belongs to Endocrine.
Why it happens
Barbiturates induce CYP3A4 (and CYP2C8), increasing repaglinide metabolism.
What to do
Monitor blood glucose and titrate repaglinide upward if needed. Reduce the dose again if the barbiturate is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Amobarbital and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital can induce hepatic enzymes and lower repaglinide concentrations, reducing glycemic control. Loss of effect may occur during chronic barbiturate use.
How serious is the interaction between Amobarbital and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and titrate repaglinide upward if needed. Reduce the dose again if the barbiturate is withdrawn.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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