Drug interactions
Amobarbital + Oxybutynin
Severity: Minor
Amobarbital and Oxybutynin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital induces CYP3A4 and may reduce oxybutynin concentrations, lessening control of bladder symptoms. Additive sedation may also occur since both can cause CNS depression.
What this interaction means in plain words
Amobarbital and Oxybutynin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amobarbital belongs to Central Nervous System; Oxybutynin belongs to Genitourinary.
Why it happens
Barbiturate-induced CYP3A4 activity increases oxybutynin metabolism.
What to do
Monitor for reduced antimuscarinic efficacy and increase oxybutynin dose if needed; counsel about drowsiness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxybutynin
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Oxybutynin?
MediHelp rates the interaction as minor. Amobarbital and Oxybutynin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amobarbital induces CYP3A4 and may reduce oxybutynin concentrations, lessening control of bladder symptoms. Additive sedation may also occur since both can cause CNS depression.
How serious is the interaction between Amobarbital and Oxybutynin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antimuscarinic efficacy and increase oxybutynin dose if needed; counsel about drowsiness.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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