Drug interactions
Amobarbital + Quinine
Severity: Moderate
Amobarbital and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and can reduce quinine concentrations, potentially leading to lower antimalarial effect. Barbiturates also add to central nervous system depression.
What this interaction means in plain words
Amobarbital and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Quinine belongs to Anti Parasitic.
Why it happens
Induction of CYP3A4 by amobarbital, increasing quinine metabolism.
What to do
Avoid the combination in treatment of malaria if possible, or monitor for treatment failure and consider a higher-monitored regimen. Watch for sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Quinine?
MediHelp rates the interaction as moderate. Amobarbital and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce hepatic enzymes and can reduce quinine concentrations, potentially leading to lower antimalarial effect. Barbiturates also add to central nervous system depression.
How serious is the interaction between Amobarbital and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in treatment of malaria if possible, or monitor for treatment failure and consider a higher-monitored regimen. Watch for sedation.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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