Drug interactions
Amobarbital + Repaglinide
Severity: Moderate
Amobarbital and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce enzymes that metabolize repaglinide and may reduce its glucose-lowering effect. Hyperglycemia may occur on starting the barbiturate, and hypoglycemia on stopping it.
What this interaction means in plain words
Amobarbital and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Repaglinide belongs to Endocrine.
Why it happens
Induction of CYP3A4 and CYP2C8 by amobarbital increases repaglinide clearance.
What to do
Monitor blood glucose when amobarbital is started, adjusted or stopped. Titrate repaglinide to glycemic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Amobarbital with Repaglinide?
MediHelp rates the interaction as moderate. Amobarbital and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce enzymes that metabolize repaglinide and may reduce its glucose-lowering effect. Hyperglycemia may occur on starting the barbiturate, and hypoglycemia on stopping it.
How serious is the interaction between Amobarbital and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when amobarbital is started, adjusted or stopped. Titrate repaglinide to glycemic response.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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