Drug interactions
Amobarbital + Sorafenib
Severity: Moderate
Amobarbital and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital may reduce sorafenib exposure through enzyme induction. Lower drug levels could diminish antitumor efficacy.
What this interaction means in plain words
Amobarbital and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Sorafenib belongs to Oncology.
Why it happens
Barbiturate induction of hepatic metabolism (CYP3A4 and glucuronidation) may increase sorafenib clearance.
What to do
Monitor for reduced tumor response and consider an alternative non-inducing agent. Dose adjustment of sorafenib may be needed if the inducer is continued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Sorafenib
Frequently asked questions
Can I take Amobarbital with Sorafenib?
MediHelp rates the interaction as moderate. Amobarbital and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital may reduce sorafenib exposure through enzyme induction. Lower drug levels could diminish antitumor efficacy.
How serious is the interaction between Amobarbital and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced tumor response and consider an alternative non-inducing agent. Dose adjustment of sorafenib may be needed if the inducer is continued.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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