Drug interactions
Amobarbital + Sunitinib
Severity: Moderate
Amobarbital and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital can lower sunitinib and its active metabolite concentrations by inducing CYP3A4. This may reduce anticancer efficacy.
What this interaction means in plain words
Amobarbital and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Sunitinib belongs to Oncology.
Why it happens
Barbiturate induction of CYP3A4 increases sunitinib clearance.
What to do
Prefer a non-inducing sedative or anticonvulsant. If the combination is unavoidable, monitor response and consider a sunitinib dose increase per labeling for strong CYP3A4 inducers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Amobarbital with Sunitinib?
MediHelp rates the interaction as moderate. Amobarbital and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital can lower sunitinib and its active metabolite concentrations by inducing CYP3A4. This may reduce anticancer efficacy.
How serious is the interaction between Amobarbital and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing sedative or anticonvulsant. If the combination is unavoidable, monitor response and consider a sunitinib dose increase per labeling for strong CYP3A4 inducers.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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