Drug interactions
Amobarbital + Suvorexant
Severity: Moderate
Amobarbital and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the CNS, so combined use increases sedation and next-day impairment. Amobarbital may also induce CYP3A4 and reduce suvorexant exposure, diminishing its hypnotic effect.
What this interaction means in plain words
Amobarbital and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Suvorexant belongs to Central Nervous System.
Why it happens
Additive CNS depression plus CYP3A4 induction by amobarbital.
What to do
Avoid routine co-use of two hypnotics; if needed, monitor for oversedation and reduced suvorexant efficacy and adjust doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Suvorexant
Frequently asked questions
Can I take Amobarbital with Suvorexant?
MediHelp rates the interaction as moderate. Amobarbital and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents depress the CNS, so combined use increases sedation and next-day impairment. Amobarbital may also induce CYP3A4 and reduce suvorexant exposure, diminishing its hypnotic effect.
How serious is the interaction between Amobarbital and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine co-use of two hypnotics; if needed, monitor for oversedation and reduced suvorexant efficacy and adjust doses accordingly.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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