Drug interactions
Amobarbital + Tadalafil
Severity: Moderate
Amobarbital and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital induces CYP3A4 and may lower tadalafil concentrations, reducing its efficacy. The effect is predicted from the mechanism and from other inducers.
What this interaction means in plain words
Amobarbital and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Tadalafil belongs to Genitourinary.
Why it happens
Barbiturate induction of CYP3A4-mediated tadalafil metabolism, increasing clearance.
What to do
Monitor for reduced response to tadalafil, and consider an alternative to the barbiturate or dose adjustment within the labeled range. Avoid the combination if tadalafil is used for pulmonary arterial hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Tadalafil?
MediHelp rates the interaction as moderate. Amobarbital and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital induces CYP3A4 and may lower tadalafil concentrations, reducing its efficacy. The effect is predicted from the mechanism and from other inducers.
How serious is the interaction between Amobarbital and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response to tadalafil, and consider an alternative to the barbiturate or dose adjustment within the labeled range. Avoid the combination if tadalafil is used for pulmonary arterial hypertension.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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