Drug interactions
Amobarbital + Tolterodine
Severity: Minor
Amobarbital and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital is an inducer of hepatic enzymes including CYP3A4 and may lower tolterodine concentrations. The effect is generally modest because the active 5-hydroxymethyl metabolite is formed via CYP2D6 and exposure to the active moiety is partly preserved. Reduced bladder symptom control is possible.
What this interaction means in plain words
Amobarbital and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amobarbital belongs to Central Nervous System; Tolterodine belongs to Genitourinary.
Why it happens
Barbiturate induction of CYP3A4 increases tolterodine clearance.
What to do
Monitor for reduced response to tolterodine and increase the dose if needed within labeled limits.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Tolterodine?
MediHelp rates the interaction as minor. Amobarbital and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amobarbital is an inducer of hepatic enzymes including CYP3A4 and may lower tolterodine concentrations. The effect is generally modest because the active 5-hydroxymethyl metabolite is formed via CYP2D6 and exposure to the active moiety is partly preserved. Reduced bladder symptom control is possible.
How serious is the interaction between Amobarbital and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response to tolterodine and increase the dose if needed within labeled limits.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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