Drug interactions
Amobarbital + Vinorelbine
Severity: Minor
Amobarbital and Vinorelbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital is an enzyme inducer and may lower exposure to vinorelbine, which is cleared mainly by CYP3A4. Reduced vinorelbine levels could blunt antitumor effect, although the clinical impact is not well characterized.
What this interaction means in plain words
Amobarbital and Vinorelbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amobarbital belongs to Central Nervous System; Vinorelbine belongs to Oncology.
Why it happens
Barbiturate induction of CYP3A4 increases hepatic metabolism of vinorelbine.
What to do
Where possible, choose a non-inducing sedative or anticonvulsant during vinorelbine therapy. If the combination is needed, monitor treatment response and hematologic toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Vinorelbine
Frequently asked questions
Can I take Amobarbital with Vinorelbine?
MediHelp rates the interaction as minor. Amobarbital and Vinorelbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amobarbital is an enzyme inducer and may lower exposure to vinorelbine, which is cleared mainly by CYP3A4. Reduced vinorelbine levels could blunt antitumor effect, although the clinical impact is not well characterized.
How serious is the interaction between Amobarbital and Vinorelbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, choose a non-inducing sedative or anticonvulsant during vinorelbine therapy. If the combination is needed, monitor treatment response and hematologic toxicity.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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