Drug interactions
Amoxapine + Dolasetron
Severity: Moderate
Amoxapine and Dolasetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a 5-HT3 antagonist with a serotonergic antidepressant has been linked to serotonin syndrome. Amoxapine also has QT-prolonging and proarrhythmic potential, which adds to dolasetron's effect on cardiac conduction.
What this interaction means in plain words
Amoxapine and Dolasetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic activity combined with additive effects on cardiac conduction and QT interval.
What to do
Watch for agitation, tremor, hyperthermia, diarrhea and neuromuscular hyperactivity after starting or increasing doses. Consider a non-serotonergic antiemetic and obtain an ECG if other QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Frequently asked questions
Can I take Amoxapine with Dolasetron?
MediHelp rates the interaction as moderate. Amoxapine and Dolasetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a 5-HT3 antagonist with a serotonergic antidepressant has been linked to serotonin syndrome. Amoxapine also has QT-prolonging and proarrhythmic potential, which adds to dolasetron's effect on cardiac conduction.
How serious is the interaction between Amoxapine and Dolasetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for agitation, tremor, hyperthermia, diarrhea and neuromuscular hyperactivity after starting or increasing doses. Consider a non-serotonergic antiemetic and obtain an ECG if other QT risk factors are present.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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