Drug interactions
Amoxapine + Eletriptan
Severity: Moderate
Amoxapine and Eletriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine inhibits serotonin and norepinephrine reuptake, so adding eletriptan may rarely produce serotonin syndrome. Evidence is limited and the risk is low.
What this interaction means in plain words
Amoxapine and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from triptan receptor agonism and amoxapine reuptake inhibition.
What to do
Monitor for serotonin syndrome after starting or increasing either drug. Discontinue the serotonergic agents if it is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Amoxapine with Eletriptan?
MediHelp rates the interaction as moderate. Amoxapine and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine inhibits serotonin and norepinephrine reuptake, so adding eletriptan may rarely produce serotonin syndrome. Evidence is limited and the risk is low.
How serious is the interaction between Amoxapine and Eletriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome after starting or increasing either drug. Discontinue the serotonergic agents if it is suspected.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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