Drug interactions
Conivaptan + Eletriptan
Severity: Contraindicated
Conivaptan and Eletriptan: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a potent CYP3A4 inhibitor and can substantially increase eletriptan exposure. This raises the risk of triptan toxicity, including hypertension and vasospasm. Eletriptan labeling warns against use with potent CYP3A4 inhibitors.
What this interaction means in plain words
Conivaptan and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Potent inhibition of CYP3A4-mediated eletriptan metabolism.
What to do
Avoid eletriptan during and for at least 72 hours after conivaptan. Select a triptan that is not a CYP3A4 substrate if needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Darunavir + Eletriptan Contraindicated
Frequently asked questions
Can I take Conivaptan with Eletriptan?
MediHelp rates the interaction as contraindicated. Conivaptan and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Conivaptan is a potent CYP3A4 inhibitor and can substantially increase eletriptan exposure. This raises the risk of triptan toxicity, including hypertension and vasospasm. Eletriptan labeling warns against use with potent CYP3A4 inhibitors.
How serious is the interaction between Conivaptan and Eletriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid eletriptan during and for at least 72 hours after conivaptan. Select a triptan that is not a CYP3A4 substrate if needed.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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