Drug interactions
Amoxapine + Ergotamine
Severity: Moderate
Amoxapine and Ergotamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine inhibits serotonin and norepinephrine reuptake, and ergotamine has serotonergic activity, so serotonin syndrome is a theoretical risk. Additive vasoconstrictive effects may also matter.
What this interaction means in plain words
Amoxapine and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects of reuptake inhibition and ergot 5-HT receptor agonism.
What to do
Monitor for serotonin syndrome and for signs of peripheral ischemia. Discontinue the agents if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Amoxapine with Ergotamine?
MediHelp rates the interaction as moderate. Amoxapine and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine inhibits serotonin and norepinephrine reuptake, and ergotamine has serotonergic activity, so serotonin syndrome is a theoretical risk. Additive vasoconstrictive effects may also matter.
How serious is the interaction between Amoxapine and Ergotamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome and for signs of peripheral ischemia. Discontinue the agents if symptoms develop.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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