Drug interactions
Amoxapine + Estradiol
Severity: Minor
Amoxapine and Estradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens have been reported to increase tricyclic antidepressant concentrations and adverse effects, while possibly blunting antidepressant response. The evidence is limited and mostly from older reports.
What this interaction means in plain words
Amoxapine and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mechanism is not well established; reduced hepatic metabolism of the tricyclic by estrogens has been suggested.
What to do
Monitor for anticholinergic effects, sedation and hypotension, and adjust the amoxapine dose to clinical response when estrogen is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Amoxapine with Estradiol?
MediHelp rates the interaction as minor. Amoxapine and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens have been reported to increase tricyclic antidepressant concentrations and adverse effects, while possibly blunting antidepressant response. The evidence is limited and mostly from older reports.
How serious is the interaction between Amoxapine and Estradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, sedation and hypotension, and adjust the amoxapine dose to clinical response when estrogen is started or stopped.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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