Drug interactions
Amoxapine + Fluconazole
Severity: Major
Amoxapine and Fluconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and fluconazole may also increase tricyclic levels by CYP inhibition. The result is a greater risk of ventricular arrhythmias including torsades de pointes.
What this interaction means in plain words
Amoxapine and Fluconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation, plus fluconazole inhibition of CYP2D6/CYP3A4-mediated metabolism of amoxapine.
What to do
Avoid the combination if possible or use a safer antidepressant. If used together, monitor the ECG and electrolytes and watch for anticholinergic and cardiac toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Amoxapine with Fluconazole?
MediHelp rates the interaction as major. Amoxapine and Fluconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and fluconazole may also increase tricyclic levels by CYP inhibition. The result is a greater risk of ventricular arrhythmias including torsades de pointes.
How serious is the interaction between Amoxapine and Fluconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible or use a safer antidepressant. If used together, monitor the ECG and electrolytes and watch for anticholinergic and cardiac toxicity.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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