Drug interactions
Domperidone + Fluconazole
Severity: Contraindicated
Domperidone and Fluconazole: contraindicated interaction.
Last updated Sources: EMA SmPC, US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Co-administration is contraindicated. Fluconazole raises domperidone plasma levels, and both drugs prolong the QT interval. Together they increase the risk of QT prolongation, torsades de pointes, serious ventricular arrhythmias, and sudden cardiac death.
What this interaction means in plain words
Domperidone and Fluconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Domperidone belongs to Gastrointestinal Tract; Fluconazole belongs to Anti Fungals.
Why it happens
Pharmacokinetic: Fluconazole is a moderate-to-strong CYP3A4 inhibitor (dose-dependent). Domperidone is extensively metabolized by CYP3A4, so fluconazole reduces its clearance and increases exposure. Pharmacodynamic: Domperidone blocks hERG channels and prolongs QTc, and fluconazole independently prolongs QTc. The effects on cardiac repolarization are additive.
What to do
Avoid the combination. If antifungal therapy is required, stop domperidone.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Other interactions of Domperidone
- Azithromycin + Domperidone Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dexlansoprazole + Domperidone Moderate
- Domperidone + Lansoprazole Moderate
- Domperidone + Pantoprazole Moderate
- Domperidone + Polyethylene Glycol 3350 Moderate
Frequently asked questions
Can I take Domperidone with Fluconazole?
MediHelp rates the interaction as contraindicated. Domperidone and Fluconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Co-administration is contraindicated. Fluconazole raises domperidone plasma levels, and both drugs prolong the QT interval. Together they increase the risk of QT prolongation, torsades de pointes, serious ventricular arrhythmias, and sudden cardiac death.
How serious is the interaction between Domperidone and Fluconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If antifungal therapy is required, stop domperidone.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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