Drug interactions
Amoxapine + Indacaterol
Severity: Moderate
Amoxapine and Indacaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine is a tricyclic-type antidepressant that can prolong the QT interval and cause tachycardia. Indacaterol may add cardiovascular stimulation and, at high exposure, QT prolongation or hypokalemia. The combination may increase the risk of ventricular arrhythmia.
What this interaction means in plain words
Amoxapine and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and adrenergic cardiovascular effects.
What to do
Monitor ECG and electrolytes in patients with cardiac disease or other QT risk factors, and keep indacaterol at the labeled dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Frequently asked questions
Can I take Amoxapine with Indacaterol?
MediHelp rates the interaction as moderate. Amoxapine and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine is a tricyclic-type antidepressant that can prolong the QT interval and cause tachycardia. Indacaterol may add cardiovascular stimulation and, at high exposure, QT prolongation or hypokalemia. The combination may increase the risk of ventricular arrhythmia.
How serious is the interaction between Amoxapine and Indacaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes in patients with cardiac disease or other QT risk factors, and keep indacaterol at the labeled dose.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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