Drug interactions
Amoxapine + Methamphetamine
Severity: Major
Amoxapine and Methamphetamine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine blocks norepinephrine reuptake and may alter the response to methamphetamine. The combination can cause hypertension, tachycardia, arrhythmia and serotonin toxicity.
What this interaction means in plain words
Amoxapine and Methamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive noradrenergic effects, with possible changes in amphetamine neuronal uptake and metabolism.
What to do
Avoid where an alternative exists. If used together, start low and monitor blood pressure, heart rate, ECG and mental status.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Amoxapine with Methamphetamine?
MediHelp rates the interaction as major. Amoxapine and Methamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amoxapine blocks norepinephrine reuptake and may alter the response to methamphetamine. The combination can cause hypertension, tachycardia, arrhythmia and serotonin toxicity.
How serious is the interaction between Amoxapine and Methamphetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid where an alternative exists. If used together, start low and monitor blood pressure, heart rate, ECG and mental status.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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