Drug interactions
Methamphetamine + Rasagiline
Severity: Contraindicated
Methamphetamine and Rasagiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rasagiline blocks MAO and reduces breakdown of monoamines released by methamphetamine. This may cause hypertensive crisis, hyperthermia and serotonin toxicity. Labeling contraindicates concurrent use.
What this interaction means in plain words
Methamphetamine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Methamphetamine belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
Why it happens
MAO inhibition potentiates methamphetamine-induced monoamine release.
What to do
Do not co-administer, and keep a 14-day interval after rasagiline. Choose a non-stimulant alternative.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Safinamide Contraindicated
- Methamphetamine + Selegiline Contraindicated
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Methamphetamine with Rasagiline?
MediHelp rates the interaction as contraindicated. Methamphetamine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rasagiline blocks MAO and reduces breakdown of monoamines released by methamphetamine. This may cause hypertensive crisis, hyperthermia and serotonin toxicity. Labeling contraindicates concurrent use.
How serious is the interaction between Methamphetamine and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer, and keep a 14-day interval after rasagiline. Choose a non-stimulant alternative.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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