Drug interactions
Methamphetamine + Safinamide
Severity: Contraindicated
Methamphetamine and Safinamide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Safinamide inhibits MAO-B, which can lead to buildup of monoamines released by methamphetamine. Hypertensive crisis and serotonin syndrome are possible. The pair is contraindicated.
What this interaction means in plain words
Methamphetamine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Methamphetamine belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
Why it happens
MAO inhibition potentiates methamphetamine-induced monoamine release.
What to do
Avoid concurrent use and wait 14 days after safinamide. Use non-stimulant therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Selegiline Contraindicated
Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Methamphetamine with Safinamide?
MediHelp rates the interaction as contraindicated. Methamphetamine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Safinamide inhibits MAO-B, which can lead to buildup of monoamines released by methamphetamine. Hypertensive crisis and serotonin syndrome are possible. The pair is contraindicated.
How serious is the interaction between Methamphetamine and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and wait 14 days after safinamide. Use non-stimulant therapy.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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