Drug interactions
Methamphetamine + Procarbazine
Severity: Contraindicated
Methamphetamine and Procarbazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine weakly inhibits MAO, so methamphetamine-released catecholamines are poorly degraded. Hypertensive crisis is a risk. The combination should be avoided.
What this interaction means in plain words
Methamphetamine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Methamphetamine belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
MAO inhibition potentiates methamphetamine-induced catecholamine release.
What to do
Avoid the combination, including for 14 days after procarbazine. Use non-sympathomimetic alternatives.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
- Methamphetamine + Selegiline Contraindicated
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Methamphetamine with Procarbazine?
MediHelp rates the interaction as contraindicated. Methamphetamine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine weakly inhibits MAO, so methamphetamine-released catecholamines are poorly degraded. Hypertensive crisis is a risk. The combination should be avoided.
How serious is the interaction between Methamphetamine and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, including for 14 days after procarbazine. Use non-sympathomimetic alternatives.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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