Drug interactions
Methamphetamine + Phenelzine
Severity: Contraindicated
Methamphetamine and Phenelzine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methamphetamine causes massive release of catecholamines, and phenelzine prevents their degradation. The result can be severe hypertensive crisis, hyperthermia, intracranial hemorrhage or serotonin toxicity. The combination is contraindicated.
What this interaction means in plain words
Methamphetamine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Methamphetamine belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Why it happens
MAO inhibition allows accumulation of norepinephrine, dopamine and serotonin released by methamphetamine.
What to do
Avoid during and for 14 days after phenelzine. Use a non-sympathomimetic alternative.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
- Methamphetamine + Selegiline Contraindicated
Frequently asked questions
Can I take Methamphetamine with Phenelzine?
MediHelp rates the interaction as contraindicated. Methamphetamine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methamphetamine causes massive release of catecholamines, and phenelzine prevents their degradation. The result can be severe hypertensive crisis, hyperthermia, intracranial hemorrhage or serotonin toxicity. The combination is contraindicated.
How serious is the interaction between Methamphetamine and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during and for 14 days after phenelzine. Use a non-sympathomimetic alternative.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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