Drug interactions
Amoxapine + Metoclopramide
Severity: Major
Amoxapine and Metoclopramide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine has dopamine-blocking activity through its metabolite and can cause extrapyramidal symptoms and tardive dyskinesia. Combined with metoclopramide the risk of these movement disorders and neuroleptic malignant syndrome is increased.
What this interaction means in plain words
Amoxapine and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive central dopamine D2 receptor antagonism.
What to do
Avoid the combination where possible and choose an antiemetic without dopamine antagonism. If unavoidable, monitor for dystonia, akathisia, parkinsonism and rigidity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Metoclopramide
Frequently asked questions
Can I take Amoxapine with Metoclopramide?
MediHelp rates the interaction as major. Amoxapine and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amoxapine has dopamine-blocking activity through its metabolite and can cause extrapyramidal symptoms and tardive dyskinesia. Combined with metoclopramide the risk of these movement disorders and neuroleptic malignant syndrome is increased.
How serious is the interaction between Amoxapine and Metoclopramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose an antiemetic without dopamine antagonism. If unavoidable, monitor for dystonia, akathisia, parkinsonism and rigidity.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Antipsychotics (e.g., haloperidol), Apomorphine. The full list is on the Metoclopramide page.
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