Drug interactions
Amoxapine + Midodrine
Severity: Moderate
Amoxapine and Midodrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine blocks norepinephrine reuptake and can potentiate or alter responses to vasopressors. With midodrine, this may produce excessive blood pressure rise or unpredictable hemodynamic effects.
What this interaction means in plain words
Amoxapine and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of norepinephrine reuptake by amoxapine modifies adrenergic responses to midodrine's alpha-1 agonism.
What to do
Monitor blood pressure, including supine readings, and heart rate when combined. Reduce midodrine dose if hypertension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Amoxapine with Midodrine?
MediHelp rates the interaction as moderate. Amoxapine and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine blocks norepinephrine reuptake and can potentiate or alter responses to vasopressors. With midodrine, this may produce excessive blood pressure rise or unpredictable hemodynamic effects.
How serious is the interaction between Amoxapine and Midodrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including supine readings, and heart rate when combined. Reduce midodrine dose if hypertension develops.
What other medicines interact with Midodrine?
MediHelp also lists interactions of Midodrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Midodrine page.
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