Drug interactions
Amoxapine + Mirtazapine
Severity: Moderate
Amoxapine and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are antidepressants with possible QT-prolonging effects, and amoxapine is also associated with arrhythmias in overdose. Combined use increases the chance of QT prolongation. It also adds to sedation and may increase serotonergic and anticholinergic burden.
What this interaction means in plain words
Amoxapine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on cardiac repolarization and additive CNS depressant effects.
What to do
Avoid combining two antidepressants unless clearly justified. If combined, obtain an ECG and monitor electrolytes and sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Amoxapine with Mirtazapine?
MediHelp rates the interaction as moderate. Amoxapine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are antidepressants with possible QT-prolonging effects, and amoxapine is also associated with arrhythmias in overdose. Combined use increases the chance of QT prolongation. It also adds to sedation and may increase serotonergic and anticholinergic burden.
How serious is the interaction between Amoxapine and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two antidepressants unless clearly justified. If combined, obtain an ECG and monitor electrolytes and sedation.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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