Drug interactions
Mirtazapine + Rasagiline
Severity: Contraindicated
Mirtazapine and Rasagiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining mirtazapine with the MAO-B inhibitor rasagiline raises the risk of serotonin syndrome and, at higher doses where selectivity is lost, of hypertensive reactions. Labeling advises against concurrent use and requires a washout between the drugs.
What this interaction means in plain words
Mirtazapine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Mirtazapine belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
Why it happens
Additive increase in synaptic serotonin and norepinephrine through MAO inhibition combined with mirtazapine's monoaminergic enhancement.
What to do
Do not co-administer; wait at least 14 days after stopping rasagiline before starting mirtazapine, and at least 14 days after stopping mirtazapine before starting rasagiline.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Selegiline Contraindicated
- Mirtazapine + Selegiline transdermal Contraindicated
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Mirtazapine with Rasagiline?
MediHelp rates the interaction as contraindicated. Mirtazapine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining mirtazapine with the MAO-B inhibitor rasagiline raises the risk of serotonin syndrome and, at higher doses where selectivity is lost, of hypertensive reactions. Labeling advises against concurrent use and requires a washout between the drugs.
How serious is the interaction between Mirtazapine and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; wait at least 14 days after stopping rasagiline before starting mirtazapine, and at least 14 days after stopping mirtazapine before starting rasagiline.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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