Drug reference
mirtazapine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Central Nervous System (Atypical Antidepressant)
Mechanism of action
Tetracyclic structure different from SSRIs, TCAs and MAOIs; through its central presynaptic alpha2-adrenergic antagonist effects, stimulates norepinephrine and serotonin release; potent antagonist of 5-HT2 and 5-HT3 serotonin and histamine receptors; is a moderate alpha1 adrenergic and muscarinic antagonist
Common side effects
- Increased appetite
- Constipation
- Somnolence
- Xerostomia
- Weight gain (>7% increase in <49% of pediatric)
Known interactions (7)
- Amlodipine/Olmesartan + mirtazapine Moderate
- bisoprolol + mirtazapine Moderate
- diazepam + mirtazapine Moderate
- dronedarone + mirtazapine Moderate
- Gliclazide + mirtazapine Moderate
- mirtazapine + Nebivolol Moderate
- mirtazapine + Sertraline Moderate
Related conditions
Frequently asked questions
What drug class is mirtazapine?
mirtazapine belongs to: Central Nervous System.
How does mirtazapine work?
Tetracyclic structure different from SSRIs, TCAs and MAOIs; through its central presynaptic alpha2-adrenergic antagonist effects, stimulates norepinephrine and serotonin release; potent antagonist of 5-HT2 and 5-HT3 serotonin and histamine receptors; is a moderate alpha1 adrenergic and muscarinic antagonist
What are the common side effects of mirtazapine?
Increased appetite, Constipation, Somnolence, Xerostomia, Weight gain (>7% increase in <49% of pediatric)
Which drugs interact with mirtazapine?
Amlodipine/Olmesartan, bisoprolol, diazepam, dronedarone, Gliclazide, Nebivolol, Sertraline
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