Drug interactions
Mirtazapine + Pimozide
Severity: Contraindicated
Mirtazapine and Pimozide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide prolongs the QT interval and can cause torsades de pointes, and mirtazapine may contribute additional QT prolongation. Together they raise the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Mirtazapine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Mirtazapine belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Additive QTc prolongation through delayed cardiac repolarization.
What to do
Avoid the combination and select an antidepressant with minimal QT effect if pimozide is required. Check baseline ECG and electrolytes if any concurrent use cannot be avoided.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mirtazapine and Pimozide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
- Mirtazapine + Selegiline transdermal Contraindicated
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Mirtazapine with Pimozide?
MediHelp rates the interaction as contraindicated. Mirtazapine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Pimozide prolongs the QT interval and can cause torsades de pointes, and mirtazapine may contribute additional QT prolongation. Together they raise the risk of serious ventricular arrhythmia.
How serious is the interaction between Mirtazapine and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and select an antidepressant with minimal QT effect if pimozide is required. Check baseline ECG and electrolytes if any concurrent use cannot be avoided.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Procarbazine. The full list is on the Mirtazapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
