Drug interactions
Amoxapine + Modafinil
Severity: Moderate
Amoxapine and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil may inhibit CYP2C19, which can raise concentrations of some tricyclic antidepressants in poor metabolizers. Amoxapine is a tricyclic-type drug, so toxicity such as sedation, anticholinergic effects or arrhythmia is theoretically possible. The pharmacodynamic effects partly oppose each other.
What this interaction means in plain words
Amoxapine and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible CYP2C19 inhibition by modafinil raising tricyclic levels, plus additive cardiovascular effects.
What to do
Monitor for tricyclic adverse effects and heart rate, and reduce the amoxapine dose if toxicity appears. Consider an ECG in patients with cardiac risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Frequently asked questions
Can I take Amoxapine with Modafinil?
MediHelp rates the interaction as moderate. Amoxapine and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Modafinil may inhibit CYP2C19, which can raise concentrations of some tricyclic antidepressants in poor metabolizers. Amoxapine is a tricyclic-type drug, so toxicity such as sedation, anticholinergic effects or arrhythmia is theoretically possible. The pharmacodynamic effects partly oppose each other.
How serious is the interaction between Amoxapine and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and heart rate, and reduce the amoxapine dose if toxicity appears. Consider an ECG in patients with cardiac risk.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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