Drug interactions
Amoxapine + Oxycodone
Severity: Moderate
Amoxapine and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combined use can cause greater drowsiness, impaired psychomotor performance and respiratory depression. Amoxapine's anticholinergic effects may also add to opioid-related constipation and urinary retention.
What this interaction means in plain words
Amoxapine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects of an opioid and a sedating tricyclic-type antidepressant.
What to do
Start with the lowest effective oxycodone dose and monitor for excessive sedation and slowed breathing, especially at initiation and after dose increases. Counsel patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Amoxapine with Oxycodone?
MediHelp rates the interaction as moderate. Amoxapine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combined use can cause greater drowsiness, impaired psychomotor performance and respiratory depression. Amoxapine's anticholinergic effects may also add to opioid-related constipation and urinary retention.
How serious is the interaction between Amoxapine and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective oxycodone dose and monitor for excessive sedation and slowed breathing, especially at initiation and after dose increases. Counsel patients to avoid driving and alcohol.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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