Drug interactions
Calcium / magnesium / potassium / sodium oxybates + Oxycodone
Severity: Contraindicated
Calcium / magnesium / potassium / sodium oxybates and Oxycodone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxybates are potent CNS depressants, and combined with opioids they markedly increase the risk of profound sedation, respiratory depression, coma and death.
What this interaction means in plain words
Calcium / magnesium / potassium / sodium oxybates and Oxycodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive CNS and respiratory depression.
What to do
Avoid the combination, as oxybate labeling contraindicates or strongly restricts concurrent opioid use. If an opioid is unavoidable, consider interrupting oxybate or choosing an alternative.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
- Oxycodone + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Calcium / magnesium / potassium / sodium oxybates with Oxycodone?
MediHelp rates the interaction as contraindicated. Calcium / magnesium / potassium / sodium oxybates and Oxycodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oxybates are potent CNS depressants, and combined with opioids they markedly increase the risk of profound sedation, respiratory depression, coma and death.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Oxycodone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, as oxybate labeling contraindicates or strongly restricts concurrent opioid use. If an opioid is unavoidable, consider interrupting oxybate or choosing an alternative.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Oxycodone page.
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