Drug interactions
Oxycodone + Phenelzine
Severity: Contraindicated
Oxycodone and Phenelzine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenelzine with oxycodone risks serotonin syndrome or severe opioid toxicity with hypotension, hyperthermia and respiratory depression. Labeling advises against use during or within 14 days of MAOI therapy.
What this interaction means in plain words
Oxycodone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Oxycodone belongs to Musculoskeletal; Phenelzine belongs to Central Nervous System.
Why it happens
MAO inhibition combined with opioid serotonergic and CNS depressant effects; exact mechanism not fully defined.
What to do
Do not co-administer and allow 14 days after stopping the MAOI before oxycodone. Use a non-opioid alternative.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
- Oxycodone + Tranylcypromine Contraindicated
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Oxycodone with Phenelzine?
MediHelp rates the interaction as contraindicated. Oxycodone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenelzine with oxycodone risks serotonin syndrome or severe opioid toxicity with hypotension, hyperthermia and respiratory depression. Labeling advises against use during or within 14 days of MAOI therapy.
How serious is the interaction between Oxycodone and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer and allow 14 days after stopping the MAOI before oxycodone. Use a non-opioid alternative.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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