Drug interactions
Isocarboxazid + Oxycodone
Severity: Contraindicated
Isocarboxazid and Oxycodone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concomitant use of opioids with MAOIs such as isocarboxazid can cause serotonin syndrome or opioid toxicity, including hypotension, hyperthermia, agitation, respiratory depression and coma. Oxycodone labeling advises against use during or within 14 days of MAOI therapy.
What this interaction means in plain words
Isocarboxazid and Oxycodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isocarboxazid belongs to Central Nervous System; Oxycodone belongs to Musculoskeletal.
Why it happens
MAO inhibition combined with opioid effects causes serotonergic and CNS depressant excess; exact mechanism is not fully defined.
What to do
Do not use oxycodone in patients taking an MAOI or within 14 days of stopping it. Choose a non-serotonergic alternative analgesic.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
- Oxycodone + Tranylcypromine Contraindicated
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Isocarboxazid with Oxycodone?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Oxycodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Concomitant use of opioids with MAOIs such as isocarboxazid can cause serotonin syndrome or opioid toxicity, including hypotension, hyperthermia, agitation, respiratory depression and coma. Oxycodone labeling advises against use during or within 14 days of MAOI therapy.
How serious is the interaction between Isocarboxazid and Oxycodone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use oxycodone in patients taking an MAOI or within 14 days of stopping it. Choose a non-serotonergic alternative analgesic.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Oxycodone page.
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