Drug interactions
Olanzapine / samidorphan + Oxycodone
Severity: Contraindicated
Olanzapine / samidorphan and Oxycodone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Samidorphan blocks opioid receptors, reducing oxycodone analgesia and potentially precipitating withdrawal in opioid-dependent patients. Overriding the blockade with higher doses risks overdose.
What this interaction means in plain words
Olanzapine / samidorphan and Oxycodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Samidorphan is a mu-opioid receptor antagonist that opposes oxycodone's agonist effects.
What to do
Allow at least 7 days opioid-free for short-acting and 14 days for long-acting oxycodone before starting. Use another antipsychotic if opioid therapy is needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
- Oxycodone + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Olanzapine / samidorphan with Oxycodone?
MediHelp rates the interaction as contraindicated. Olanzapine / samidorphan and Oxycodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Samidorphan blocks opioid receptors, reducing oxycodone analgesia and potentially precipitating withdrawal in opioid-dependent patients. Overriding the blockade with higher doses risks overdose.
How serious is the interaction between Olanzapine / samidorphan and Oxycodone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Allow at least 7 days opioid-free for short-acting and 14 days for long-acting oxycodone before starting. Use another antipsychotic if opioid therapy is needed.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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