Drug interactions
Amoxapine + Pregabalin
Severity: Moderate
Amoxapine and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and psychomotor impairment, and combining them can increase drowsiness, dizziness and cognitive slowing. Pregabalin with other CNS depressants has also been linked to respiratory depression, particularly in older or compromised patients.
What this interaction means in plain words
Amoxapine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression through pharmacodynamic synergism.
What to do
Start with the lowest effective doses and monitor for sedation and respiratory depression. Warn the patient about driving and operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pregabalin
Frequently asked questions
Can I take Amoxapine with Pregabalin?
MediHelp rates the interaction as moderate. Amoxapine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and psychomotor impairment, and combining them can increase drowsiness, dizziness and cognitive slowing. Pregabalin with other CNS depressants has also been linked to respiratory depression, particularly in older or compromised patients.
How serious is the interaction between Amoxapine and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective doses and monitor for sedation and respiratory depression. Warn the patient about driving and operating machinery.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
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