Drug interactions
Amoxapine + Ranolazine
Severity: Moderate
Amoxapine and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine and amoxapine can each prolong the QT interval. Used together they may add to this effect and raise the risk of torsades de pointes, especially with electrolyte disturbances or structural heart disease.
What this interaction means in plain words
Amoxapine and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation through cardiac repolarisation (potassium channel) effects.
What to do
Obtain a baseline ECG and repeat it after starting the combination. Correct potassium and magnesium, and choose a non-QT-prolonging antidepressant if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Amoxapine with Ranolazine?
MediHelp rates the interaction as moderate. Amoxapine and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine and amoxapine can each prolong the QT interval. Used together they may add to this effect and raise the risk of torsades de pointes, especially with electrolyte disturbances or structural heart disease.
How serious is the interaction between Amoxapine and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat it after starting the combination. Correct potassium and magnesium, and choose a non-QT-prolonging antidepressant if the QTc becomes markedly prolonged.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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