Drug interactions
Carbamazepine + Ranolazine
Severity: Contraindicated
Carbamazepine and Ranolazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine is a potent CYP3A4 inducer and substantially lowers ranolazine concentrations. This can result in loss of antianginal efficacy.
What this interaction means in plain words
Carbamazepine and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Carbamazepine belongs to Central Nervous System; Ranolazine belongs to Cardiovascular.
Why it happens
Induction of CYP3A4 and P-gp increasing ranolazine clearance.
What to do
Do not coadminister; ranolazine labeling contraindicates strong CYP3A inducers. Use an alternative antianginal or anticonvulsant.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
- Cobicistat + Ranolazine Contraindicated
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Ranolazine?
MediHelp rates the interaction as contraindicated. Carbamazepine and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Carbamazepine is a potent CYP3A4 inducer and substantially lowers ranolazine concentrations. This can result in loss of antianginal efficacy.
How serious is the interaction between Carbamazepine and Ranolazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; ranolazine labeling contraindicates strong CYP3A inducers. Use an alternative antianginal or anticonvulsant.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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