Drug reference
ranolazine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Anti Anginal)
Mechanism of action
Antianginal effects not determined, but does not depend on HR or BP reduction; no effect on rate-pressure product at maximal exercise; shown to inhibit cardiac late sodium current (INA) at therapeutic levels
Common side effects
- Angioedema
- Constipation
- Dizziness
- Headache
- Nausea
Contraindications
- Hepatic cirrhosis, including Child-Pugh class A (mild), B (moderate), and C (severe) Strong CYP3A inhibitors (eg, ketoconazole, itraconazole, clarithromycin, nefazodone, nelfinavir, ritonavir, indinavir, saquinavir) CYP3A inducers (eg, carbamazepine, phenobarbital, phenytoin, rifampin, rifabu…
Known interactions (15)
- enzalutamide + ranolazine Contraindicated
- itraconazole + ranolazine Contraindicated
- ketoconazole + ranolazine Contraindicated
- ranolazine + rifampin Contraindicated
- dronedarone + ranolazine Major
- efavirenz + ranolazine Major
- griseofulvin + ranolazine Major
- amlodipine + ranolazine Moderate
- aprepitant + ranolazine Moderate
- chloramphenicol + ranolazine Moderate
- colchicine + ranolazine Moderate
- dasatinib + ranolazine Moderate
- everolimus + ranolazine Moderate
- fluconazole + ranolazine Moderate
- fluvoxamine + ranolazine Moderate
Related conditions
Frequently asked questions
What drug class is ranolazine?
ranolazine belongs to: Cardiovascular.
How does ranolazine work?
Antianginal effects not determined, but does not depend on HR or BP reduction; no effect on rate-pressure product at maximal exercise; shown to inhibit cardiac late sodium current (INA) at therapeutic levels
What are the common side effects of ranolazine?
Angioedema, Constipation, Dizziness, Headache, Nausea
Which drugs interact with ranolazine?
enzalutamide, itraconazole, ketoconazole, rifampin, dronedarone, efavirenz, griseofulvin, amlodipine, aprepitant, chloramphenicol, colchicine, dasatinib, everolimus, fluconazole, fluvoxamine
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