Drug interactions
Amoxapine + Sevoflurane
Severity: Moderate
Amoxapine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine is a tricyclic-type antidepressant with anticholinergic, alpha-blocking and proarrhythmic properties. With sevoflurane, hypotension and arrhythmias may be more likely, although the clinical data are limited.
What this interaction means in plain words
Amoxapine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive cardiovascular effects, including alpha-adrenergic blockade, conduction effects and QT-related changes; the exact mechanism is not firmly established.
What to do
Monitor ECG and blood pressure during anesthesia. Treat hypotension with direct-acting vasopressors and avoid indirect-acting sympathomimetics.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Frequently asked questions
Can I take Amoxapine with Sevoflurane?
MediHelp rates the interaction as moderate. Amoxapine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine is a tricyclic-type antidepressant with anticholinergic, alpha-blocking and proarrhythmic properties. With sevoflurane, hypotension and arrhythmias may be more likely, although the clinical data are limited.
How serious is the interaction between Amoxapine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and blood pressure during anesthesia. Treat hypotension with direct-acting vasopressors and avoid indirect-acting sympathomimetics.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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