Drug interactions
Amoxapine + Tedizolid
Severity: Moderate
Amoxapine and Tedizolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tedizolid is a weak reversible MAO inhibitor, and amoxapine inhibits norepinephrine and serotonin reuptake. Serotonin syndrome is possible, although clinical trial data with tedizolid showed little serotonergic effect.
What this interaction means in plain words
Amoxapine and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Potential additive serotonergic effect from weak MAO inhibition and monoamine reuptake inhibition.
What to do
Monitor for serotonin syndrome symptoms such as agitation, tremor, clonus and hyperthermia. Consider an alternative antibiotic in patients with high serotonergic burden.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Frequently asked questions
Can I take Amoxapine with Tedizolid?
MediHelp rates the interaction as moderate. Amoxapine and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tedizolid is a weak reversible MAO inhibitor, and amoxapine inhibits norepinephrine and serotonin reuptake. Serotonin syndrome is possible, although clinical trial data with tedizolid showed little serotonergic effect.
How serious is the interaction between Amoxapine and Tedizolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome symptoms such as agitation, tremor, clonus and hyperthermia. Consider an alternative antibiotic in patients with high serotonergic burden.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
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