Drug interactions
Methamphetamine + Tedizolid
Severity: Major
Methamphetamine and Tedizolid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tedizolid is a weak reversible MAO inhibitor, and methamphetamine releases monoamines and blocks their reuptake. Together they could raise the risk of serotonin toxicity or hypertensive reactions. Clinical data with tedizolid are limited, and the risk is probably lower than with linezolid.
What this interaction means in plain words
Methamphetamine and Tedizolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Methamphetamine belongs to Central Nervous System; Tedizolid belongs to Anti Bacterial.
Why it happens
Additive serotonergic and sympathomimetic effects from weak MAO inhibition by tedizolid combined with monoamine release by methamphetamine.
What to do
Avoid the combination where an alternative antibiotic is available. If it must be used, monitor for agitation, tremor, hyperthermia, clonus and blood pressure rise, and stop one agent if they occur.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methylene blue + Tedizolid Major
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Methamphetamine with Tedizolid?
MediHelp rates the interaction as major. Methamphetamine and Tedizolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tedizolid is a weak reversible MAO inhibitor, and methamphetamine releases monoamines and blocks their reuptake. Together they could raise the risk of serotonin toxicity or hypertensive reactions. Clinical data with tedizolid are limited, and the risk is probably lower than with linezolid.
How serious is the interaction between Methamphetamine and Tedizolid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative antibiotic is available. If it must be used, monitor for agitation, tremor, hyperthermia, clonus and blood pressure rise, and stop one agent if they occur.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
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