Drug interactions
Bupropion + Tedizolid
Severity: Major
Bupropion and Tedizolid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tedizolid is a weak reversible MAO inhibitor, and bupropion is contraindicated with MAO inhibitors. Clinical serotonergic effects with tedizolid have been low in studies, but a hypertensive or neurotoxic reaction remains possible. The interaction is mostly theoretical.
What this interaction means in plain words
Bupropion and Tedizolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bupropion belongs to Central Nervous System; Tedizolid belongs to Anti Bacterial.
Why it happens
Weak MAO inhibition by tedizolid may potentiate noradrenergic and dopaminergic effects of bupropion.
What to do
Use an alternative antibiotic if feasible. If combined, monitor blood pressure and for signs of serotonin toxicity and neuroexcitation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bupropion and Tedizolid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Tedizolid
Frequently asked questions
Can I take Bupropion with Tedizolid?
MediHelp rates the interaction as major. Bupropion and Tedizolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tedizolid is a weak reversible MAO inhibitor, and bupropion is contraindicated with MAO inhibitors. Clinical serotonergic effects with tedizolid have been low in studies, but a hypertensive or neurotoxic reaction remains possible. The interaction is mostly theoretical.
How serious is the interaction between Bupropion and Tedizolid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic if feasible. If combined, monitor blood pressure and for signs of serotonin toxicity and neuroexcitation.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
