Drug interactions
Meperidine + Tedizolid
Severity: Major
Meperidine and Tedizolid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tedizolid is a weak reversible MAO inhibitor, and meperidine is a serotonergic opioid, so serotonin syndrome is theoretically possible. Clinical data with tedizolid have shown a low serotonergic risk, but caution is still warranted given the severity of meperidine-MAOI reactions.
What this interaction means in plain words
Meperidine and Tedizolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Meperidine belongs to Musculoskeletal; Tedizolid belongs to Anti Bacterial.
Why it happens
Reversible MAO inhibition by tedizolid combined with meperidine's serotonergic activity may elevate serotonin.
What to do
Prefer a non-serotonergic opioid during tedizolid therapy. If both are needed, monitor for serotonin syndrome symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Tedizolid
Frequently asked questions
Can I take Meperidine with Tedizolid?
MediHelp rates the interaction as major. Meperidine and Tedizolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tedizolid is a weak reversible MAO inhibitor, and meperidine is a serotonergic opioid, so serotonin syndrome is theoretically possible. Clinical data with tedizolid have shown a low serotonergic risk, but caution is still warranted given the severity of meperidine-MAOI reactions.
How serious is the interaction between Meperidine and Tedizolid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-serotonergic opioid during tedizolid therapy. If both are needed, monitor for serotonin syndrome symptoms.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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