Drug interactions
Amoxicillin + Aspirin
Severity: Minor
Amoxicillin and Aspirin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates can reduce renal tubular secretion of penicillins and may displace them from plasma proteins, possibly raising amoxicillin levels slightly. The effect is usually small, but high-dose aspirin combined with a penicillin may add to bleeding tendency.
What this interaction means in plain words
Amoxicillin and Aspirin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion secretion and plasma protein binding.
What to do
No dose adjustment is usually needed; monitor for bleeding in patients taking high-dose aspirin or with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amoxicillin
- Amoxicillin + Methotrexate Major
- Amoxicillin + Bcg vaccine live Moderate
- Amoxicillin + Cholera vaccine Moderate
- Amoxicillin + Eravacycline Moderate
- Amoxicillin + Microbiota Moderate
- Amoxicillin + Mycophenolate Moderate
Frequently asked questions
Can I take Amoxicillin with Aspirin?
MediHelp rates the interaction as minor. Amoxicillin and Aspirin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salicylates can reduce renal tubular secretion of penicillins and may displace them from plasma proteins, possibly raising amoxicillin levels slightly. The effect is usually small, but high-dose aspirin combined with a penicillin may add to bleeding tendency.
How serious is the interaction between Amoxicillin and Aspirin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor for bleeding in patients taking high-dose aspirin or with renal impairment.
What other medicines interact with Amoxicillin?
MediHelp also lists interactions of Amoxicillin with, for example, Methotrexate, Bcg vaccine live, Cholera vaccine. The full list is on the Amoxicillin page.
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