Drug interactions
Amoxicillin + Erythromycin base
Severity: Minor
Amoxicillin and Erythromycin base: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
In vitro, bacteriostatic macrolides can blunt the activity of beta-lactams against actively dividing bacteria. Clinical evidence for reduced efficacy is limited and inconsistent.
What this interaction means in plain words
Amoxicillin and Erythromycin base have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical pharmacodynamic antagonism between a bacteriostatic protein synthesis inhibitor and a bactericidal cell-wall-active agent.
What to do
No routine change is needed. Review clinical response if both are used for a serious infection.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amoxicillin
- Amoxicillin + Methotrexate Major
- Amoxicillin + Bcg vaccine live Moderate
- Amoxicillin + Cholera vaccine Moderate
- Amoxicillin + Eravacycline Moderate
- Amoxicillin + Microbiota Moderate
- Amoxicillin + Mycophenolate Moderate
Frequently asked questions
Can I take Amoxicillin with Erythromycin base?
MediHelp rates the interaction as minor. Amoxicillin and Erythromycin base have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. In vitro, bacteriostatic macrolides can blunt the activity of beta-lactams against actively dividing bacteria. Clinical evidence for reduced efficacy is limited and inconsistent.
How serious is the interaction between Amoxicillin and Erythromycin base?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Review clinical response if both are used for a serious infection.
What other medicines interact with Amoxicillin?
MediHelp also lists interactions of Amoxicillin with, for example, Methotrexate, Bcg vaccine live, Cholera vaccine. The full list is on the Amoxicillin page.
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