Drug interactions
Amoxicillin + Pyridoxine
Severity: Minor
Amoxicillin and Pyridoxine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral antibiotics may alter gut flora that contribute to B vitamin availability. Clinically meaningful pyridoxine deficiency from a short amoxicillin course is not expected.
What this interaction means in plain words
Amoxicillin and Pyridoxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical alteration of intestinal flora affecting vitamin supply.
What to do
No action is needed for short courses. Consider the nutritional status of patients on prolonged antibiotic therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amoxicillin and Pyridoxine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amoxicillin
- Amoxicillin + Methotrexate Major
- Amoxicillin + Bcg vaccine live Moderate
- Amoxicillin + Cholera vaccine Moderate
- Amoxicillin + Eravacycline Moderate
- Amoxicillin + Microbiota Moderate
- Amoxicillin + Mycophenolate Moderate
Frequently asked questions
Can I take Amoxicillin with Pyridoxine?
MediHelp rates the interaction as minor. Amoxicillin and Pyridoxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral antibiotics may alter gut flora that contribute to B vitamin availability. Clinically meaningful pyridoxine deficiency from a short amoxicillin course is not expected.
How serious is the interaction between Amoxicillin and Pyridoxine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed for short courses. Consider the nutritional status of patients on prolonged antibiotic therapy.
What other medicines interact with Amoxicillin?
MediHelp also lists interactions of Amoxicillin with, for example, Methotrexate, Bcg vaccine live, Cholera vaccine. The full list is on the Amoxicillin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
